Findings: (First Image)Axial T2-weighted image shows evidence of edema in both posterior parietal/occipital regions, with abnormal signal involving the corpus callosum. (Second and Third Images) Axial T1 and coronal T1-weighted images post-contrast demonstrate intense enhancement of a lesion which is crossing the corpus callosum. The major differential diagnosis is primary CNS lymphoma versus glioblastoma multiforme.
Diagnosis: Primary CNS lymphoma
Discussion: Primary CNS lymphoma is a non-Hodgkin lymphoma, usually B-cell origin, which represents 1 - 2% of all primary CNS tumors. It occurs with increased frequency in patients with AIDS, but may occur in non-AIDS patients as well. Although the tumors are radiosensitive, the overall prognosis is poor, with a median survival after diagosis +/- of 13.5 months, with chemotherapy and radiation treatment.
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