uhrad.com - Women's Diagnostic Imaging Teaching FilesCase Three - Ductal Adenocarcinoma of the Breast

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Clinical History: 50-year-old white female, placed on hormone therapy. Question of left breast fullness, with two palpable left axillary lymph nodes. Only a simple cyst seen on mammography - confirmed by ultrasound.

Findings: Enhancing focal mass with additional diffuse infiltration on MR in a patient with negative mammogram.

10/13/95
Left axillary lymph node biopsy positive for poorly differentiated metastatic adenocarcinoma. Breast likely origin, GI or lung primary less likely. Estrogen and progesterone receptor negative.

10/10/95
MRI of Breast. Images 23 + 24: T1 weighted pregadolinium. Subtle focal asymmetry in left lateral breast. No focal mass. Two 1 cm. nodes in left axilla and inflammatory changes from node biopsy. (The retroareolar simple cyst was visualized on more inferior cuts). Images 169 + 171: Fast spin echo T1 - postgadolinium. 2 cm. focal enhancing mass in lateral aspect of left breast in region of asymmetry. Inferiorly, diffuse, scattered enhancing tissue, not visualized on pregadolinium images.

11/6/95
Follow-up mammogram. Dense breasts with simple cyst on left. No change from 7/18/95 and no evidence of malignancy.

Pathology: Invasive poorly differeintiated ductal adenocarcinoma. Extensive ductal carcinoma in situ, comedo and noncomedo type.

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Submitted by:
Anne H. Nicklas, M.D>
Sutek Lie, M.D.